Mary-Louise Parker's romantic relationships are as intriguing and dramatic as her career. Parker's life was changed when Billy Crudup fell in love with Claire Danes and Parker was understandably mad at the tabloids for writing about this difficult time in her life. Whether she's talking about this situation or her acting roles, her interviews are always interesting and clever because she doesn't hold back.
Several years ago, when Mary-Louise Parker starred in Weeds, she was interviewed by David Letterman. Instead of getting some juicy details about her romantic life, viewers were surprised when Letterman commented on Parker's physical appearance. It was definitely a surprising segment...
David Letterman Talked About Mary-Louise Parker's Body In This Unforgettable Interview
David Letterman interviewed Mary-Louise Parker while she was still playing Nancy Botwin on the popular TV series Weeds. Before she left, the late-night host commented on her looks. It felt like the comment came out of nowhere. It was even stranger because he brought up her two children before complimenting one of her body parts.
Letterman said:
"Well, you got your hands full now. You got the kids and a great a**."
Parker took the moment in stride. Instead of acting offended or telling Letterman that he said the wrong thing, she said, "Yeah. What more could I ask for?"
Letterman seemed to realize that he had made a shocking comment and made a joke before he finished up the segment. He said, "I won't be here tomorrow." He then added that audiences could watch Weeds on Showtime and said, "Good luck with the Emmy nomination."
Mary-Louise Parker's Emmy Nominations (According to Emmys.com) |
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Outstanding Supporting Actress In A Drama Series (2002, The West Wing) |
Outstanding Supporting Actress In A Miniseries Or Movie (2004, Angels In America) - won |
Outstanding Lead Actress In A Miniseries Or Movie (2007, The Robber Bride) |
Outstanding Lead Actress In A Comedy Series (2007, Weeds) |
Outstanding Lead Actress In A Comedy Series (2008, Weeds) |
Outstanding Lead Actress In A Comedy Series (2009, Weeds) |

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Some Of Mary-Louise Parker's Most Notable Roles:
- Nancy Botwin in Weeds (2005-2012)
- Ruth Jamison in Fried Green Tomatoes (1991)
- Janey Patterson in Mr. Mercedes (2017)
- Amy Gardner in The West Wing (2001-2006)
- Harper Pitt in Angels In America (2003)
At the time of her interview on The Late Show With David Letterman, Mary-Louise Parker was beloved thanks to her role on Weeds. Throughout eight seasons, she brought a raw vulnerability to the role of a mother who goes down a dark path while trying to provide for her kids and find out who she is.
Mary-Louise Parker's Career Accomplishments (According to Brittanica.com) |
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won a Golden Globe Award for Weeds |
won a Tony Award for the Broadway play Proof |
her memoir "Dear Mr. You" was published in 2015 |
While no one would blame another celebrity for saying that David Letterman should never have commented on Mary-Louise Parker's butt. Parker smiled and didn't look angry or offended. Based on what she has said in several interviews about being a well-known actress, it doesn't seem like she takes the industry too seriously. That could be why she seemed to simply shrug this moment off. Of course, fans can't really know what she thought about this moment. However, at the very least, she didn't look annoyed during the interview.
In an interview with The Guardian in 2023, Parker talked about her celebrity status. She often seems very cool and collected during interviews, and that seems to be because she takes a calm approach to her career.

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Parker talked about moving to Brooklyn after living on a farm in New York for a while along with the inspiration she got from her friend Laura Linney. Parker said, “Laura takes the subway, and it’s like Laura, you know, she went to theater school and she keeps doing theater. We have a similar thing where we’re not, like, running for office in Hollywood.”
Mary-Louise Parker Had Several Other Memorable David Letterman Interviews
Mary-Louise Parker appeared on The Late Show With David Letterman Show several times. While no appearance was as memorable as when he complimented one of her body parts, there were a few other conversations that stood out.
According to Gothamist, in 2009, Parker talked about bedbugs with David Letterman. She said, "They don't burrow into your body but they burrow into your life."
What Fans Should Know About Mary-Louise Parker's Children (According to Closer Weekly):
- William Atticus Parker (born 2004), father is Billy Crudup
- Caroline "Ash" Aberash, adopted in 2007
Parker shared that she could tell that there were bedbugs in her house because her son William's arm had a few bites. She asked someone to come see what was going on. Parker's description of bedbugs was dramatic and intense. There's no doubt that a few viewers were squeamish when listening to her recount this story.

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Parker talked about William with David Letterman quite often. According to The Huffington Post, she also said that William felt upset that Weeds was going off the air in 2012. She said, "He’s sad. He thinks I’m on a show about gardening." She added that William said that he could give her his allowance if it meant that she could continue acting on Weeds.
Since Mary-Louise Parker was interviewed on The Late Show with David Letterman quite often, viewers could assume that she was never upset about anything that he said to her. She doesn't appear to have shared her opinion about the former late-night host. If she had something to say, it seems likely that she would be honest as she doesn't tend to hold back. For example, when the actress wrote her memoir "Dear Mr. You," she shared her thoughts on the different men she has encountered throughout her life.